Close Menu

Jialing Xiang

Jialing Xiang, M.D., Ph.D.

Professor of Biology
Chair of Biology Graduate Affairs Committee

Phone: 

312.567.3491

Fax: 

312.567.3494

Office: 

294 Life Sciences Building

Education 

M.D. Xuzhou Medical College
Ph.D. University of Alabama at Birmingham

Research & Accomplishments 

The work in my laboratory is focused on answering the basic biological questions at the molecular level related to human diseases. The research areas include program cell death, signaling transduction, and cellular protein membrane trafficking. One of the major projects involves proapoptotic Bcl-2 family members, such as Bax and Bad. We identified a unique Bax isoform, which may serve as a prognostic marker for cancer chemotherapy. We also defined a broad signaling interplay between apoptotic pathway and other signaling pathways, involving many pathological events, such as hormone refractory and inflammation. We believe that study of the cellular signaling process will help our understanding of the molecular basis of human diseases and identify cellular targets for the effective treatment.

Expertise 

  • Molecular cell biology
  • Signaling network
  • Programmed cell death
  • Cancer biology

Publications 

  • Zhang H, Lin Y, Manas A, Zhao Y, Denning MF, Ma L, Xiang, J. (2014) Bax∆2 promotes apoptosis through caspase-8 activation in microsatellite unstable colon cancer. Mol. Cancer Res. 12(9), 1225-23.
  • Haferkamp, B., Zhang, H., Kissinger, S., Xin, W., Lin, Y., Schultz, M., Xiang, J. (2013) BaxΔ2 family alternative splicing salvages Bax microsatellite-frameshift mutations. Genes & Cancer. 4, 501-512.
  • Yan, J., Xiang, J., Lin, Y., Ma, J., Zhang, J., Zhang, H., Sun, J., Danial, N., Liu, J., Lin, A. (2013). Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation. Cell. 152(1), 304-315.
  • Lin, Y., Lu, Z., Kokontis, J., Xiang, J. (2013). Androgen receptor primes prostate cancer cells to apoptosis through down-regulation of basal p21 expression. Biochem. Biophys. Res. Commun. 430(1), 289-93.
  • Haferkamp, B., Zhang, H., Lin, Y., Yeap. X, Bounce, A., Sharpe, J., Xiang, J. (2012). BaxΔ2 is a novel Bax isoform unique to microsatellite unstable tumors. J. Biol. Chem. 287(41), 34722-9.
  • Godfrey, B., Lin, Y., and Xiang, J. (2010). Structure and function analysis of the pro-death domains of androgen receptor in prostate cancer cells. Cell Res. 20: 1138-1140.
  • Tang F, Kokontis J, Lin Y, Liao S, Lin A, Xiang, J. (2009).Androgen via p21 inhibits TNF-alpha-induced JNK activation and apoptosis. J. Biol. Chem. 284(47), 32353-8.
  • Deng, H., Yu, F., Chen, J., Zhao, Y., Xiang, J., Lin, A. (2008). Phosphorylation of bad at Thr201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1. J. Biol.Chem. 283(30):20754-60.
  • Lin, Y., Fukuchi, J., Hiipakka, R., Kokontis, J., and Xiang, J. Up-regulation of Bcl-2 is required for the progression of prostate cancer cells from androgen-dependent to androgen-independent growth. Cell Res. 17(6), 531-536 (2007).
  • Lin, Y., Kokontis, J., Tang, F., Liao, S., Lin, A., Chen, C., and Xiang, J. Androgen and Its Receptor AR Promote BAX-mediated Apoptosis. Mol. Cell. Biol. 26(5), 1908 –1916 (2006).
  • Yu, C., Minemoto, Y., Zhang, J., Liu, J., Tang, F., Bui, T., Lin, A.* and Xiang, J*. Activation of the JNK pathway inhibits IL-3 withdrawal induced apoptosis in B-lymphocytes.  Molecular Cell. 13, 329-340 (2004).
  • Xiang, J., Gomez-Navarro, J, Arafat, W., Liu B., Barker, S.D., Alvarez, R.D., Siegal G.P., and Curiel, D.T. Pro-apoptotic treatment with an adenovirus encoding bax enhances the effect of chemotherapy in ovarian cancer.  J. Gene Medicine 2(2), 97-106 (2000).
  • Xiang, J., Chao, D.T., and Korsmeyer, S.J. Bax-induced cell death may not require interleukin 1 b-converting enzyme-like proteases. Proc. Natl. Acad. Sci. USA. 93, 14559-14563 (1996).