Hyun-soon Chong, Ph.D.
Research & Accomplishments
The Chong group’s research involves organic synthesis, medicinal chemistry, synthetic methodology development, bioconjugate chemistry, bioanalytical chemistry, bioinorganic chemistry, biochemistry, and antibody drug conjugate (ADC) chemistry.
The current research interest is centered on interdisciplinary research projects aimed at developing safe, effective, and targeted drugs for cancer and neurodegenerative diseases including small molecule inhibitors, bioconjugates, and nuclear medicine. We have developed several promising cancer therapeutic and imaging agents with successful preclinical profiles that are favorably compared to the existing anti-cancer drugs and radiopharmaceuticals.
The Chong group is specialized in chemistry of aziridinium ions as versatile and reactive intermediate compounds in organic synthesis of enantiomerically enriched molecules. We have conducted synthetic and mechanistic studies of the strained and labile aziridinium ions and utilized aziridinium ion chemistry for development of biologically active molecules and macrocyclic and acyclic chelating agents for biomedical and environmental health applications.
The following are selected publications.
Kang CS, Ren S, Sun X, Chong HS. Theranostic Polyaminocarboxylate-Cyanine-Transferrin Conjugate for Anticancer Therapy and Near-Infrared Optical Imaging. ChemMedChem. 2016, 11, 2188-2193.
Wu N, Kang CS, Sin I, Ren S, Liu D, Ruthengael VC, Lewis MR, Chong HS. Promising Bifunctional Chelators for Copper 64-PET imaging: Practical 64Cu Radiolabeling and High In Vitro and In Vivo Complex Stability. Journal of Biological Inorganic Chemistry 2016, 21, 177–184.
Chen Y, Sun X, Wu N, Li J, Jin S, Zhong Y, Liu Z, Rogachev A, Chong HS. Synthetic and Theoretical Investigation on One-Pot Halogenation of β-Amino Alcohols and Nucleophilic Ring Opening of Aziridinium Ions. Organic Biomolecular Chemistry 2016, 14, 920-939.
Kang CS, Wu N, Chen Y, Sun X, Bandara N, Liu D, Lewis MR, Rogers BE, Chong HS. Transferrin Conjugates of Triazacyclononane-Based Bifunctional NE3TA Chelates for PET Imaging: Synthesis, Cu-64 Radiolabeling, and In vitro and In vivo evaluation. Journal of Inorganic Biochemistry 2016, 154, 60-66.
Sun X, Chen Y, Wu N, Kang CS, Song HA, Jin S, Fu Y, Bryant Jr H, Frank JA, Chong HS. Application of Aziridinium Ring Opening for Preparation of Optically Active Diamine and Triamine Analogues: Highly Efficient Synthesis and Evaluation of DTPA-Based MRI Contrast Enhancement Agents. RSC Advances 2015, 5, 94571-94581.
Chong HS, Sun X, Chen Y, Sin I, Kang CS, Lewis MR, Liu D, Ruthengael VC, Zhong Y, Wu N, Song HA. Synthesis and Comparative Biological Evalution of Bifunctional Ligands for Radiotherapy Applications of 90Y and 177Lu. Bioorganic Medicinal Chemistry 2015, 23, 1169-1178.
Kang CS, Chen Y, Lee HB, Liu D, Sun X, Kweon J, Lewis MR, Chong HS. Synthesis and Evaluation of a New Bifunctional NETA Chelate for Molecular Targeted Radiotherapy Using 90Y or 177Lu. Nuclear Medicine and Biology 2015, 42, 242–249.
Chong HS, Sun X, Zhong Y, Barber K, Lewis MR, Liu D, Ruthengael VC, Sin I, Kang CS. Synthesis and Evaluation of an Enantiomerically Enriched Bifunctional Chelator for 64Cu-Based Positron Emission Tomography (PET) imaging. European Journal of Organic Chemistry. 2014, 1305–131.
Chong HS, Chen Y. Stereoselective and Regioselective Intramolecular Friedel-Crafts Reaction of Aziridinium Ions for Synthesis of 4-Substituted Tetrahydroisoquinolines. Organic Letters 2013, 15, 5912-5915.
Kang CS, Song HA, Milenic DE, Baidoo KE, Brechbiel MW, Chong HS. Preclinical Evaluation of NETA-Based Bifunctional Ligand for Radioimmunotherapy Applications Using Bi-212 and Bi-213: Radiolabeling, Serum Stability, and Biodistribution and Tumor Uptake Studies. Nuclear Medicine Biology 2013, 40, 600-605.
Kang CS, Sun X, Jia F, Song HA, Chen Y, Lewis MR, Chong HS. Synthesis and Preclinical Evaluation of Bifunctional Ligands for Improved Chelation Chemistry of Y-90 and Lu-177 for Targeted Radioimmunotherapy. Bioconjugate Chemistry 2012, 23, 1775-1782.
Chong HS, Sun X, Dong P, Kang CS. Convenient Synthesis and Evaluation of Heptadentate Bifunctional Ligand for Radioimmunotherapy Applications. European Journal of Organic Chemistry 2011, 6641-6648.
Song HA, Kang CS, Baidoo KE, Milenic DE, Chen Y, Dai A, Brechbiel MW, Chong HS. Efficient Bifunctional Decadentate Ligand 3p-C-DEPA for Targeted Alpha-Radioimmunotherapy Applications. Bioconjugate Chemistry 2011, 22, 1128-1135.
Chong HS, Song HA, Kang CS, Le T, Sun X, Dadwal M, Lee H, Lan X, Chen Y, and Dai A. A Highly Effective Bifunctional Ligand for Radioimmunotherapy Applications. Chemical Communications 2011, 47, 5584-5586.
Chong HS, Song HA, Dadwal M, Sun X, Sin I, Chen Y. Efficient Synthesis of Functionalized Aziridinium Salts. Journal of Organic Chemistry 2010, 75, 219-221.
Chong HS, Song HA, Ma X, Lim SY, Mhaske S, Sun X. Novel Bile Acid-Based Polyaminocarboxylates as Targeted Antitumor Agents. Chemical Communications 2009, 3011–3013.
Chong HS, Ma X, Le T, Kwamena B, Milenic DE, Song HA, Brady ED, Brechbiel MW. Rational Design and Generation of Bimodal Bifunctional Ligand for Antibody-Targeted Radiation Cancer Therapy. Journal of Medicinal Chemistry 2008, 51, 118–125.
Chong HS, Ma X, Lee HS, Bui P, Song HA, Birch N. Synthesis and Evaluation of Novel Polyaminocarboxylate-Based Antitumor Agents. Journal of Medicinal Chemistry 2008, 51, 2208–2215.